(NEW YORK) — A pandemic of the novel coronavirus has now killed more than 1.18 million people worldwide.

Over 45 million people across the globe have been diagnosed with COVID-19, the disease caused by the new respiratory virus, according to data compiled by the Center for Systems Science and Engineering at Johns Hopkins University. The actual numbers are believed to be much higher due to testing shortages, many unreported cases and suspicions that some national governments are hiding or downplaying the scope of their outbreaks. The criteria for diagnosis — through clinical means or a lab test — has also varied from country to country.

The United States is the worst-affected nation, with more than 8.9 million diagnosed cases and at least 228,668 deaths.

Nearly 200 vaccine candidates for COVID-19 are being tracked by the World Health Organization, at least 10 of which are in crucial phase three studies. Of those 10 potential vaccines in late-stage trials, there are currently five that will be available in the United States if approved.

Here’s how the news is developing Friday. All times Eastern:

Oct 30, 5:28 am
Global cases top 45 million, US nears nine million

As the number of new cases of COVID-19 surge across Europe and the United States, the global total of diagnosed coronavirus cases is now over 45 million, according to a count kept by Johns Hopkins University.

There are at least 8,945,891 cases as of 4 a.m. Friday in the U.S. and the country will likely hit nine million cases before the end of the day as cases, hospitalizations and deaths from the virus are increasing.

The U.S. on Thursday saw a record single-day high of coronavirus cases with more than 88,000 reported, according to the COVID Tracking Project. Deaths are up 3.6% week-over-week, while new cases are up 24.8% and the test-positivity rate increased to 6.2% from 6% over the same seven-day period, according to an internal Health and Human Service memo obtained by ABC News.

Forty-three states and territories are in an upward trajectory of new cases, while eight jurisdictions are at a plateau and five are going down, the HHS memo said.

Meanwhile, Europe now accounts for 46% of global coronavirus cases.

This month, many countries in the continent, such as France and Spain, have declared states of emergency, while many others are imposing more restrictions so that ICUs do not become overwhelmed.

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